HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium cyanoborohydride → 5-Methoxy-6-(trifluoromethyl)indoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 5-Methoxy-6-(trifluoromethyl)-1H-indole | HCID 10822552 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Methoxy-6-(trifluoromethyl)indoline | HCID 11206713 | 99% |
Reaction Steps
The indole (D10) (67.63 g, 0.315 mol) was treated with sodium cyanoborohydride (40 g, 0.637 mol) in glacial acetic acid (500 ml) as in the method of Description 1 to afford the title indoline (67.73 g, 99%) as an off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06638953B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-a5c2e55e2d2e4702883145ed28f80446 |
| Source note | uspto-grants-2003_10 |