5-Methoxy-6-(trifluoromethyl)indoline → HCID 10646133, compound

HRID 989209Notes

Reaction equation

HRID 989209 reaction equation
C1(O[C:8](=[O:23])[NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][C:21]=3[CH3:22])[CH:11]=2)C=CC=CC=1.[CH3:24][O:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][C:34]=1[C:35]([F:38])([F:37])[F:36])[NH:31][CH2:30][CH2:29]2>>[CH3:22][C:21]1[CH:20]=[CH:19][N:18]=[CH:17][C:16]=1[C:12]1[CH:11]=[C:10]([NH:9][C:8]([N:31]2[C:32]3[C:28](=[CH:27][C:26]([O:25][CH3:24])=[C:34]([C:35]([F:37])([F:38])[F:36])[CH:33]=3)[CH2:29][CH2:30]2)=[O:23])[CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 112067135-Methoxy-6-(trifluoromethyl)indolineHCID 18005168HCID 18005168, compound

Product 1

HCID 10646133HCID 10646133, compoundYield 34%

Procedure

Reaction of phenyl-N-[3-(4-methylpyrid-3-ylphenyl]carbamate (D28) (0.4 g, 1.3 mmoles) with 5-methoxy-6-trifluoromethylindoline (D1)1) (0.28 g, 1.3 mmoles) as in the method of Example 28 gave the title compound (E41) (0.19 g, 34%) m.p. 178-180° C.

Sources & evidence

ORD record
ord-9dc8f946685b451687ce706be5f343c7
Source dataset
uspto-grants-2003_10
Patent number
US06638953B2

Reaction notes

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