Sulfur → 4-[(3-Formyl-4-pyridinyl)methyl]benzonitrile

Participants

Reaction Conditions

Reaction Steps

The product obtained in Step A (2 g/0.0058 mol) is brought to solution in 80 ml of Decalin, and then 0.336 g (0.010 mol) of sulphur is added, and the whole is heated at 140-150° C. for 24 hours. The reaction mixture is filtered and then concentrated. A brown oil is obtained, which is purified by chromatography over silica gel (heptane, 10% AcOEt 10%) to yield the title product.

Provenance & Evidence