1-{[4-(Chloromethyl)phenyl]methyl}-1H-pyrrole → HCID 9946192, compound

HRID 989266Notes

Reaction equation

HRID 989266 reaction equation
Cl[CH2:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][N:8]2[CH:12]=[CH:11][CH:10]=[CH:9]2)=[CH:5][CH:4]=1.[OH:15][C:16]1[CH:27]=[CH:26][C:19]([CH2:20][N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)=[CH:18][CH:17]=1>>[N:21]1([CH2:20][C:19]2[CH:26]=[CH:27][C:16]([O:15][CH2:2][C:3]3[CH:14]=[CH:13][C:6]([CH2:7][N:8]4[CH:12]=[CH:11][CH:10]=[CH:9]4)=[CH:5][CH:4]=3)=[CH:17][CH:18]=2)[CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 155859181-{[4-(Chloromethyl)phenyl]methyl}-1H-pyrroleHCID 187719784-(Pyrrolidin-1-ylmethyl)phenol

Product 1

HCID 9946192HCID 9946192, compound

Procedure

The title compound was prepared starting from 1-(4-chloromethyl-benzyl)-pyrrole and 4-hydroxybenzyl-pyrrolidine by the same method described in Example 19. 1H NMR (400 MHz, MeOD-d4)δ7.18 (m, 2 H), 6.99 (m, 2 H), 6.59 (t, J=2.1 Hz, 2 H), 5.97 (t, J=2.1 Hz, 2 H), 4.99 (s, 2 H), 3.55 (s, 2 H), 2.41 (m, 4 H), 1.70 (m, 4 H).

Sources & evidence

ORD record
ord-0d7fe3ca1c834568b0c8f79c4a4d4e86
Source dataset
uspto-grants-2003_10
Patent number
US06638967B2

Reaction notes

Loading…