HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 989268Generated: October 30, 2026
Benzylamine → Benzyl-(4pyrrolidin1-ylmethyl-phenyl)-amine
https://huagongshe.com/reaction/989268
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| Reactant | 1-(4-Bromobenzyl)pyrrolidine | HCID 12738004 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Benzyl-(4pyrrolidin1-ylmethyl-phenyl)-amine | HCID 9965193 | — |
Reaction Steps
The mixture of 4-bromobenzyl-pyrrolidine (1 equiv, 120 mg), Pd2(dba)3 (2.0% equiv, 9.15 mg), t-Bu3P (1.6% equiv, 1.6 mg), benzylamine (1 equiv, 53.6 mg) and NaOtBu3 (1.5 equiv, 72 mg) in toluene (5 mL) was heated at 70° C. for 8 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06638967B2 |
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| Source dataset | uspto-grants-2003_10 |
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| ORD ID | ord-8cfca8e7f9ec40489ccd493084e74b70 |
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| Source note | uspto-grants-2003_10 |
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