HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobenzenesulfonyl chloride → N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-bromobenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobenzenesulfonyl chloride | HCID 520403 | — |
| Reactant | 3-Methoxy-5-methyl-2-pyrazinamine | HCID 10701894 | — |
| Product | N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-bromobenzenesulfonamide | HCID 22574647 | — |
Reaction Steps
2-amino-3-methoxy-5-methylpyrazine (1.50 g, 10.8 mmol; synthesized according to Bradbury, R. H., et. al. J. Med. Chem. 1997, 40, 996-1004) and 2-bromobenzenesulfonyl chloride (2.80 g, 11.0 mmol) were reacted according to the procedure of Example 25, Step A. 44A was a pink solid, 2.0 g (52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06638937B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-8cbe911632b74a319ed4b8b8eec582b8 |
| Source note | uspto-grants-2003_10 |