Carbon tetrabromide → HCID 18005873, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (7-hydroxychroman-2-yl)methanol (6.18 g, 34.3 mmol) and CBr4 (19.3 g, 58.3 mmol) in CH2Cl2 is treated with a solution of triphenylphosphine (9.0 g, 34.3 mmol) in CH2Cl2 at 0° C., stirred at 0° C. for 6 hr and concentrated in vacuo to give a residue. The residue is purified by column chromatography (silica gel, 60% CH2Cl2 in hexanes as eluent) to give the title product as an oil, 4.61 g (55% yield), identified by NMR and mass spectral analyses.

Provenance & Evidence