3-Amino-1-propanol → HCID 10799880, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromomethyl-7-hydroxychroman (4.57 g, 18.8 mmol) and 3-amino-1-propanol (18.3 mL, 240 mmol) is heated at 100° C. for 2 hr, cooled, diluted with water and extracted with CH2Cl2. The combined extracts are concentrated in vacuo to give a residue. The residue is purified by column chromatography (silica gel/5% methanol in CH2Cl2 as eluent) to give the title product as a clear oil, 3.27 g (73% yield) identified by NMR and mass spectral analyses.

Provenance & Evidence