HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Azido-6-nitro-4-(4-phenoxyanilino)-3-quinolinecarbonitrile → 6,7-Diamino-4-(4-phenoxyanilino)-3-quinolinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Azido-6-nitro-4-(4-phenoxyanilino)-3-quinolinecarbonitrile | HCID 21956459 | — |
| Reactant | HCID 21956473 | HCID 21956473 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6,7-Diamino-4-(4-phenoxyanilino)-3-quinolinecarbonitrile | HCID 21956466 | 119.7% |
Reaction Steps
Following the procedure of 6,7-diamino-4-(3,4,5-trimethoxyanilino)-3-quinolinecarbonitrile (intermediate from Example 33), hydrogenation of a suspension of 736.0 mg (1.74 mmol) of 7-azido-6-nitro-4-(4-phenoxyanilino)-3-quinolinecarbonitrile and 147.2 mg of 10% palladium-on-carbon in 21 mL of THF and 6 mL of ethanol yields 765.1 mg of crude 6,7-diamino-4-(4-phenoxyanilino)-3-quinolinecarbonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06638929B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-8a20dc8bdd814d10bc32ea1934f0b5ec |
| Source note | uspto-grants-2003_10 |