反应详情

A mixture of 200 mg (0.88 mmol) of 4-chlorobenzo[4,5]furo[3,2-b]pyridine-3-carbonitrile and 180 mg (0.96 mmol) of 4-phenoxyaniline in 5 mL of 2-ethoxyethanol is heated at reflux temperature for 3 hours. The reaction mixture is cooled to room temperature and partitioned between ethyl acetate and saturated sodium bicarbonate. The organic layer is washed with saturated sodium bicarbonate, followed by brine, then dried over sodium sulfate and filtered through a pad of diatomaceous earth. Concentration in vacuo yields 115 mg (35%) of a beige solid, mp 175-179° C.

1. temperatureis heated
2. temperatureat reflux temperature for 3 hours
3. custompartitioned between ethyl acetate and saturated sodium bicarbonate
4. washThe organic layer is washed with saturated sodium bicarbonate
5. dry with materialdried over sodium sulfate
6. filtrationfiltered through a pad of diatomaceous earth
7. concentrationConcentration in vacuo