Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Aminophenylacetic acid ethyl ester | HCID 225219 | — |
| Reactant | 3-(1-Ethoxy-1-phenyl-methylidene)-5-phenylsulphonylamino-2-indolinone | HCID 69510549 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178470689 | HCID 178470689 | — |
Reaction Steps
0.84 g (2 mmol) of 3-(1-ethoxy-1-phenyl-methylidene)-5-phenylsulphonylamino-2-indolinone and 0.39 g (2.2 mmol) of 4-ethoxycarbonylmethyl-aniline are dissolved in 10 ml of DMF. The mixture is heated to 140° C. for 5 hours. Then water is added while the mixture is cooled with ice and stirred for 1 hour at ambient temperature. The precipitate formed is suction filtered, washed with water, a little isopropanol and ether, then dried in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06638965B2 |
|---|
| Source dataset | uspto-grants-2003_10 |
|---|
| ORD ID | ord-9e8e9983e8e648419ddb4873b515846b |
|---|
| Source note | uspto-grants-2003_10 |
|---|
