Sodium Hydroxide → HCID 178525187, compound

HRID 989407Notes

Reaction equation

HRID 989407 reaction equation
C([O:3][C:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]/[C:14](=[C:21]2\[C:22](=[O:40])[NH:23][C:24]3[C:29]\2=[CH:28][C:27]([NH:30][S:31]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)(=[O:33])=[O:32])=[CH:26][CH:25]=3)/[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][CH:8]=1)=[O:5])C.[OH-].[Na+]>CO.ClCCl>[C:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]/[C:14](=[C:21]2\[C:22](=[O:40])[NH:23][C:24]3[C:29]\2=[CH:28][C:27]([NH:30][S:31]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)(=[O:33])=[O:32])=[CH:26][CH:25]=3)/[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:9][CH:8]=1)([OH:5])=[O:3]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 178470689HCID 178470689, compound

Product 1

HCID 178525187HCID 178525187, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
40 °C

Procedure

720 mg (1.3 mmol) of (Z)-3-[1-(4-ethoxycarbonylmethyl-phenylamino)-1-phenyl-methylidene]-5-phenylsulphonylamino-2-indolinone are dissolved in a mixture of 20 ml of methanol and 20 ml of dichloromethane. 4 ml of 1 N sodium hydroxide solution are added and the mixture is stirred for 18 hours at ambient temperature and for another 1 hour at 40° C. The reaction solution is evaporated down to half the volume and the pH is adjusted to 4-5 with 1 N hydrochloric acid. The precipitate formed is suction filtered, washed with water, a little isopropanol and ether.

Workup

  1. customThe reaction solution is evaporated down to half the volume
  2. customThe precipitate formed
  3. filtrationfiltered
  4. washwashed with water

Sources & evidence

ORD record
ord-754f21d5c0a141d4bbbe9e1eea2b4589
Source dataset
uspto-grants-2003_10
Patent number
US06638965B2

Reaction notes

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