HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → 2-[4-[[(Z)-[5-(benzenesulfonamido)-2-oxo-1H-indol-3-ylidene]-phenylmethyl]amino]phenyl]-N-benzylacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178525187 | HCID 178525187 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-[4-[[(Z)-[5-(benzenesulfonamido)-2-oxo-1H-indol-3-ylidene]-phenylmethyl]amino]phenyl]-N-benzylacetamide | HCID 178520294 | — |
Reaction Steps
A solution of 315 mg (0.6 mmol) of (Z)-3-[1-(4-carboxymethyl-phenylamino)-1-phenyl-methylidene]-5-phenylsulphonylamino-2-indolinone, 85 mg (0.8 mmol) of benzylamine, 212 mg (0.66 mmol) of TBTU and 1 ml of N-ethyl-N,N-diisopropyl-amine in 5 ml of DMF is stirred for 3 hours at ambient temperature. Then 50 ml of water are added. The yellow precipitate formed is suction filtered, washed with water, a little isopropanol and ether, then dried in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06638965B2 |
| Source dataset | uspto-grants-2003_10 |
| ORD ID | ord-53761e58622a4651817d1becc0812d54 |
| Source note | uspto-grants-2003_10 |