Hydrochloric Acid → HCID 57425272, compound

Participants

Reaction Steps

Hydrochloride of methyl ester of L-phenylalanine (5.95 g) and benzophenoneimine (5.00 g) were added to methylene chloride (100 ml), and they were stirred at room temperature overnight. A solid thus formed was filtered out of the reaction mixture. The filtrate was concentrated under reduced pressure. Diethyl ether (100 ml) was added to the residue. A solid thus formed was again filtered out of the reaction mixture. The ether layer was washed with water (100 ml) and then dried over anhydrous magnesium sulfate. Magnesium sulfate was removed, and the solution in ether was concentrated to obtain the intended methyl ester of N-(diphenylmethylene)-L-phenylalanine (9.44 g) in a yield of 99.6%.

Provenance & Evidence