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HRID989492

反应详情

EQUATION

反应方程式

HRID 989492 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OB(c2ccc(CC#N)cc2)OC1(C)C
HCID3842922

[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetonitrile

C14H18BNO2

结构：CC(C)S(=O)(=O)N[C@@H]1CCC[C@H]1c1ccc(I)cc1
HCID11784171

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)S(=O)(=O)N[C@@H]1CCC[C@H]1c1ccc(-c2ccc(CC#N)cc2)cc1
HCID69112880

未命名化合物

收率 68.1%

PROCEDURE

实验过程

(+,−) Trans propane-2-sulfonic acid [2-(4-iodo-phenyl)-cyclopentyl]-amide (356 mg, 0.91 mmol, prepared in example 2) and [4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetonitrile (275 mg, 1.13 mmol) were treated as described in example 6. The product was chromatographed on Chromatotron® eluting with 99.5:0.5 methylene chloride:ethyl acetate to afford 237 mg (68%) of the title compound as a white solid. The NMR was consistent with the assigned structure.

WORKUP

后处理

  1. customThe product was chromatographed on Chromatotron®
  2. washeluting with 99.5:0.5 methylene chloride