cis-[(Methylethyl)sulfonyl][2-(4-nitrophenyl)cyclopentyl]amine → cis-[2-(4-Aminophenyl)cyclopentyl][(methylethyl)sulfonyl]amine

Participants

Reaction Steps

(+,−) Cis propane-2-sulfonic acid [2-(4-nitro-phenyl)-cyclopentyl]-amide (200 mg, 0.64 mmol, prepared in example 22) was dissolved in 25 mL of ethanol and hydrogenated over 25 mg of 5% Pd/C at room temperature overnight at 413.69 kPa (60 psi). The solution was filtered through celite and concentrated in vacuo to 142 mg (78%) of a colorless oil which was used directly.

Provenance & Evidence