Formic Acid → HCID 178448051, compound

HRID 989578Notes

Reaction equation

HRID 989578 reaction equation
[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C@H:10]2[CH2:15][CH2:14][C@H:13]([CH2:16][CH2:17][CH:18]3OCCC[O:19]3)[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)[CH2:2][CH3:3].C(O)=O>C1(C)C=CC=CC=1>[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C@H:10]2[CH2:15][CH2:14][C@H:13]([CH2:16][CH2:17][CH:18]=[O:19])[CH2:12][CH2:11]2)[CH2:6][CH2:5]1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 284Formic AcidHCID 178448040HCID 178448040, compound

Product 1

HCID 178448051HCID 178448051, compoundYield 97.6%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In 3.0 l of toluene was dissolved 300 g (930 mmol) of the 2-(2-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)ethyl)-1,3-dioxane obtained by the procedures described above, 428 g (9300 mmol) of formic acid was added thereto, and they were heated to reflux for 4 hours. The reaction mixture was washed with 600 ml of saturated aqueous sodium bicarbonate solution twice and with 1.0 l of water five times, and the solvent was distilled off under a reduced pressure to obtain 240 g of a crude 3-(trans-4-(trans-4-propylcyclohexyl)-cyclohexyl)propanal.

Workup

  1. customobtained by the procedures
  2. additionwas added
  3. temperaturethey were heated
  4. temperatureto reflux for 4 hours
  5. washThe reaction mixture was washed with 600 ml of saturated aqueous sodium bicarbonate solution twice
  6. distillationwith 1.0 l of water five times, and the solvent was distilled off under a reduced pressure

Sources & evidence

ORD record
ord-045f10c1840c4ea9b918c68476a5e9cc
Source dataset
uspto-grants-2002_10
Patent number
US06458433B1

Reaction notes

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