反应详情

In 500 ml of toluene was dissolved 50.0 g (171 ml ) of the crude 1-methoxy-4-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)butene obtained by the procedures in the fourth step, 78.7 g (1710 mmol) of formic acid was added thereto, and then they were heated to reflux for 4 hours. The reaction mixture was washed with 300 ml of saturated aqueous sodium bicarbonate solution twice and with 500 ml of water five times, and the solvent was distilled off under a reduced pressure to obtain 45.1 g of a crude 4-(trans-4-(trans-4-propylcyclohexyl)cyclohexyl)butanal.

1. additionwas added
2. temperaturethey were heated
3. temperatureto reflux for 4 hours
4. washThe reaction mixture was washed with 300 ml of saturated aqueous sodium bicarbonate solution twice
5. distillationwith 500 ml of water five times, and the solvent was distilled off under a reduced pressure