Sodium borohydride → HCID 18417984, compound

HRID 989598Notes

Reaction equation

HRID 989598 reaction equation
[BH4-].[Na+].[Cl:3][C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[C:6]([Cl:14])[C:5]=1[N:15]1[C:19]([NH:20][C:21](OCC)=O)=[C:18]([CH2:26][S:27][CH3:28])[C:17]([C:29]#[N:30])=[N:16]1>CO>[Cl:14][C:6]1[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=[C:4]([Cl:3])[C:5]=1[N:15]1[C:19]([NH:20][CH3:21])=[C:18]([CH2:26][S:27][CH3:28])[C:17]([C:29]#[N:30])=[N:16]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 17979878HCID 17979878, compound

Product 1

HCID 18417984HCID 18417984, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sodium borohydride (420 mg) was added portionwise to a solution of 1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-ethoxycarbonylamino-4-methylthiomethlpyrazole (854 mg) in methanol. The mixture was evaporated, diluted with dichloromethane and water, and the organic phase dried (magnesium sulfate) and evaporated to give 1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-5-methylamino-4-methylthiomethylpyrazole.

Workup

  1. customThe mixture was evaporated
  2. additiondiluted with dichloromethane and water
  3. dry with materialthe organic phase dried (magnesium sulfate)
  4. customevaporated

Sources & evidence

ORD record
ord-e8f34502f96c4a71ac3956d993ec4b81
Source dataset
uspto-grants-2002_10
Patent number
US06458744B2

Reaction notes

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