Water → HCID 70022904, compound

Participants

Reaction Steps

To a solution of the enol ether 2 (0.5 g, 1.52 mmol) in dichloromethane (30 mL), THF (20 mL) and methanol (20 mL) was added water (30 mL) followed by oxalic acid dihydrate (1.2 g, 9.5 mmol) and the resulting biphasic mixture was vigorously stirred for 8.5 h. The layers were separated and the aqueous layer washed with dichloromethane (2×20 mL). The organic layers were combined, dried over anhydrous potassium carbonate and concentrated to give the ketone 3 as a glassy solid (0.47 g, 98%).

Provenance & Evidence