Hydrazine hydrate (1:1) → HCID 70005314, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-[(E)-4-phthalimido-2-butenyl]-1H-imidazo[4,5-b]pyridine (2.19 g, 6.87 mmol) in ethanol (100 mL) at room temperature was treated with hydrazine monohydrate (3.33 mL, 68.7 mmol). After 10 min., the reaction mixture was warmed to 60° C. for 2 h, allowed to cool to 25° C, and recooled to 0° C. in an ice bath. The resulting slurry was filtered, and the filtrate was concentrated in vacuo. Purification by flash chromatography (6% NH4OH/ethanol) afforded 0.92 g of the title compound; mass (CI) m/z=211 (M+H).

Provenance & Evidence