Succinic anhydride → HCID 86758533, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 150 mg of 3-[1-methyl-4[1-methyl-4[1-methyl-4[1-methyl-5(α-bromoacrylamido) indole-2-carboxamido]pyrrole-2-carboxamido]pyrrole-2-carboxamido]pyrrole-2-carboxamido]propionamidine hydrochloride, prepared as described in step I as above, in 10 ml DMF were added 25 mg of potassium carbonate and 20 mg of succinic anhydride. The mixture was heated at 60° C. for 4 hours. The solvent evaporated under vacuum and the crude residue purified by flash chromatography (methylene chloride/methanol:8/2) to yield 100 mg of the title compound as a yellow powder.

Provenance & Evidence