HCID 53979657, compound → HCID 53747305, compound

Participants

Reaction Steps

A mixture of methyl (±)-8-[(benzyloxycarbonyl)amino]-2-methyl-3-oxo-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate (1.5 g), Pearlman's catalyst (0.30 g), and warm AcOH (300 mL) was stirred under H2 (balloon pressure). After 90 min, the mixture was filtered to remove the catalyst, and the filtrate was concentrated to give the title compound as a viscous oil (1 g, 100%): 1H NMR (CDCl3) δ7.00 (br s, 2H), 6.88 (d, J=8.1 Hz, 1H), 6.57 (dd, J=8.1, 2.3 Hz, 1H), 6.43 (d, J=2.3 Hz, 1H), 5.25 (d, J=16.3 Hz, 1H), 3.78 (m, 1H), 3.70 (s, 3H), 3.68 (d, J=16.3 Hz, 1H), 3.03 (s, 3H), 3.00-2.80 (m, 3H), 2.40 (dd, J=16.7, 5.3 Hz, 1H).

Provenance & Evidence