Water → HCID 10145303, compound

Participants

Reaction Steps

A mixture of Compound B of Example 27 (95.2 mg, 0.2 mmol) and N-phenylmethoxyl methanesulfamide (44 mg, 0.22 mmol) was stirred with potassium carbonate (69 mg, 0.5 mmol) in DMF (1 mL) at 70-80° C. for 2 hours. Water (10 mL) was added and the precipitates were collected. The solids were dried in vacuo and redissolved in DCM. The DCM solution was filtered and the filtrate solution was concentrated to afford the title compound as a colorless foam, 119.0 mg (100%) MS m/e 597 (M+H)+.

Provenance & Evidence