o-Toluenesulfonyl chloride → HCID 70159655, compound

HRID 989688Notes

Reaction equation

HRID 989688 reaction equation
Cl.[C:2]([C:4]1[CH:5]=[CH:6][C:7]2[N:13](CC3C=NC=CC=3)[CH2:12][C@@H:11]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[N:10]([S:28]([C:31]3SC=[CH:34][CH:35]=3)(=[O:30])=[O:29])[CH2:9][C:8]=2[CH:36]=1)#[N:3].[C:37]1(C)[C:38](S(Cl)(=O)=O)=CC=[CH:41][CH:42]=1>>[CH3:41][C:42]1[CH:37]=[CH:38][C:31]([S:28]([N:10]2[CH2:9][C:8]3[CH:36]=[C:4]([C:2]#[N:3])[CH:5]=[CH:6][C:7]=3[NH:13][CH2:12][C@H:11]2[CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)(=[O:29])=[O:30])=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 8623o-Toluenesulfonyl chlorideHCID 131723534HCID 131723534, compound2×

Product 1

HCID 70159655HCID 70159655, compound

Procedure

The title compound was prepared from Compound A of Example 23 and toluenesulfonyl chloride following the procedure of Compound B of Example 23.

Sources & evidence

ORD record
ord-398409d3b9664ec7957646bb9e267d72
Source dataset
uspto-grants-2002_10
Patent number
US06458783B1

Reaction notes

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