Pentylamine → HCID 12043757, compound

HRID 989699Notes

Reaction equation

HRID 989699 reaction equation
[CH2:1]([C:5]1[C:6](Cl)=[N:7][C:8]([NH2:12])=[N:9][C:10]=1[CH3:11])[CH2:2][CH2:3][CH3:4].[CH2:14]([NH2:19])[CH2:15][CH2:16][CH2:17][CH3:18]>>[NH2:12][C:8]1[N:7]=[C:6]([NH:19][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[C:10]([CH3:11])[N:9]=1

Participants

3

Reactant 2

HCID 8060PentylamineHCID 27531785-Butyl-4-chloro-6-methylpyrimidin-2-amine

Product 1

HCID 12043757HCID 12043757, compoundYield 78%

Procedure

A mixture of 5-butyl-4-chloro-6-methylpyrimidine-2-yl amine (100 mg, 0.5 mmol) and amylamine (2 ml) was refluxed for 11 hours. The reaction mixture was cooled and the solvent was removed in vacuo and the residue was purified by silica gel column chromatography (MeOH:CHCl3=1:20) to give the object compound (98 mg, 78%) as an oil.

Workup

  1. temperaturewas refluxed for 11 hours
  2. temperatureThe reaction mixture was cooled
  3. customthe solvent was removed in vacuo
  4. customthe residue was purified by silica gel column chromatography (MeOH:CHCl3=1:20)

Sources & evidence

ORD record
ord-775ff53afd324a588f8fccdfe86c481c
Source dataset
uspto-grants-2002_10
Patent number
US06458798B1

Reaction notes

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