Pentylamine → HCID 12043760, compound

HRID 989702Notes

Reaction equation

HRID 989702 reaction equation
[CH2:1]([C:5]1[C:10]([CH3:11])=[C:9](Cl)[N:8]=[C:7]([NH2:13])[N:6]=1)[CH2:2][CH2:3][CH3:4].[CH2:14]([NH2:19])[CH2:15][CH2:16][CH2:17][CH3:18]>>[NH2:13][C:7]1[N:8]=[C:9]([NH:19][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:10]([CH3:11])=[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])[N:6]=1

Participants

3

Reactant 2

HCID 8060PentylamineHCID 22313241HCID 22313241, compound

Product 1

HCID 12043760HCID 12043760, compoundYield 42.7%

Procedure

A mixture of 4-butyl-6-chloro-5-methylpyrimidine-2-ylamine (93.5 mg, 0.47 mmol) and amylamine (1.5 ml) was refluxed for 8 hours. After reaction, the procedure according to pro-treatment of Example 7 was carried out to give the object compound (50 mg, 42.7%).

Workup

  1. temperaturewas refluxed for 8 hours
  2. customAfter reaction

Sources & evidence

ORD record
ord-39a6732157d2437a8bee00834792dbf6
Source dataset
uspto-grants-2002_10
Patent number
US06458798B1

Reaction notes

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