Ethanol, reaction products with ammonia, distn. residues → HCID 22313256, compound

HRID 989703Notes

Reaction equation

HRID 989703 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:5]([CH3:14])=[C:4]([CH3:15])[N:3]=1.[NH3:16].C(O)C>>[NH2:16][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:5]([CH3:14])=[C:4]([CH3:15])[N:3]=1

Participants

3

Reactant 2

HCID 22020343Ethanol, reaction products with ammonia, distn. residuesHCID 22313250HCID 22313250, compound

Product 1

HCID 22313256HCID 22313256, compoundYield 3.5%

Procedure

A mixture of N-(2-chloro-5,6-dimethylpyrimidine-4-yl)-N-pentylamine (131 mg, 0.575 mmol) and 5M ammonia-ethanol (40 ml) was kept at 170° C. for 10 hours. The reaction mixture was concentrated in vacuo, purified by preparative TLC (20%MeOH/CHCl3) to give the object compound (4.2 mg, 3.5%).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. custompurified by preparative TLC (20%MeOH/CHCl3)

Sources & evidence

ORD record
ord-1e9f825bfd98443db40288d8b5463638
Source dataset
uspto-grants-2002_10
Patent number
US06458798B1

Reaction notes

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