Pentylamine → HCID 22313254, compound

HRID 989706Notes

Reaction equation

HRID 989706 reaction equation
Cl[C:2]1[C:7]([CH2:8][CH3:9])=[C:6]([CH3:10])[N:5]=[C:4]([NH2:11])[N:3]=1.[CH2:12]([NH2:17])[CH2:13][CH2:14][CH2:15][CH3:16]>O1CCOCC1>[NH2:11][C:4]1[N:3]=[C:2]([NH:17][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[C:7]([CH2:8][CH3:9])=[C:6]([CH3:10])[N:5]=1

Participants

4

Reactant 2

HCID 8060PentylamineHCID 6764624-chloro-5-ethyl-6-methylpyrimidin-2-amine

Product 1

HCID 22313254HCID 22313254, compoundYield 58.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 4-chloro-5-ethyl-6-methylpyrimidine-2-ylamine (400 mg,33 mmol), amylamine (1.35 ml) and dioxane (5 ml) was kept at 95-100° C. for 17 hours. The procedure according to pro-treatment of Example 23 was carried out to give the object compound (301 mg, 58.1%).

Sources & evidence

ORD record
ord-173c612098e643c3a047eab016dc208c
Source dataset
uspto-grants-2002_10
Patent number
US06458798B1

Reaction notes

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