Pentylamine → HCID 22313255, compound

HRID 989709Notes

Reaction equation

HRID 989709 reaction equation
Cl[C:2]1[C:7]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][N:5]=[C:4]([NH2:16])[N:3]=1.[CH2:17]([NH2:22])[CH2:18][CH2:19][CH2:20][CH3:21]>O1CCOCC1>[NH2:16][C:4]1[N:3]=[C:2]([NH:22][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[C:7]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][N:5]=1

Participants

4

Reactant 2

HCID 8060PentylamineHCID 22313251HCID 22313251, compound

Product 1

HCID 22313255HCID 22313255, compoundYield 79.7%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 4-chloro-5-phenethylpyrimidine-2-ylamine (234 mg, 1 mmol), amylamine (0.58 ml) and dioxane (2 ml) was kept at 95-100° C. for 8.5 hours. The procedure according to pro-treatment of Example 27 was carried out to give the object compound (227 mg, 79.7%).

Sources & evidence

ORD record
ord-3ff62f6515c74097b2a17cc6c6a3fe76
Source dataset
uspto-grants-2002_10
Patent number
US06458798B1

Reaction notes

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