Methyl phenylacetate → 5-Benzyl-3-(1-methyl-4-phenyl-butyl)-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one

HRID 989735Notes

Reaction equation

[NH2:1][C:2]1[N:6]([CH:7]([CH3:17])[CH2:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:5]=[N:4][C:3]=1[C:18]([NH2:20])=[O:19].[C:21]1([CH2:27][C:28](OC)=O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:27]([C:28]1[NH:20][C:18](=[O:19])[C:3]2[N:4]=[N:5][N:6]([CH:7]([CH3:17])[CH2:8][CH2:9][CH2:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:2]=2[N:1]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

Reactant 2

HCID 7559Methyl phenylacetate

HCID 111499925-Amino-1-(1-methyl-4-phenyl-butyl)-1H-[1,2,3]triazole-4-carboxamide

Product 1

HCID 1354943555-Benzyl-3-(1-methyl-4-phenyl-butyl)-3,6-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-7-one

Procedure

Analogously to the procedure of Example 1, the title compound is prepared from 566 mg (2 mmol) of 5-amino-1-(1-methyl-4-phenyl-butyl)-1H-[1,2,3]triazole-4-carboxamide and 1.16 g (7.7 mmol) of methyl phenylacetate.

Sources & evidence

ORD record: ord-f4dd9e77ff3248b6845294af742aa14c
Source dataset: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06458796B1

Reaction notes

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