Pyridine → HCID 10984336, compound

Participants

Reaction Conditions

Reaction Steps

2-(6-Indol-1-ylmethyl-pyridin-2-ylmethyl)-isoindole-1,3-dione (2.70 g, 7.35 mmol) was dissolved in dichloromethane (50 ml) and cooled to 0° C. Oxalylchloride (0.63 ml, 7.35 mmol) was added and the reaction kept at 0° C. for 30 minutes before the addition of N-hydroxysuccinimide (0.85 g, 7.35 mmol) followed by careful addition of pyridine (1.19 ml, 14.7 mmol). The reaction was kept at 0° C. for 30 minutes before it was allowed to slowly regain room temperature during 3 hours and then washed with water (40 ml) and brine (2×50 ml). The organic layer was dried over MgSO4 followed by removal of the solvent in vacuo to obtain the sub-title product (3.34 g, 85%).

Provenance & Evidence