HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methoxyacetyl chloride → 3-[4-(2-Methoxyacetylamino)-1,3-dioxoisoindolin-2-yl]-2,6-dioxo-5-acetoxypiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methoxyacetyl chloride | HCID 96623 | — |
| Reactant | 3-(4-Amino-1,3-dioxoisoindolin-2-yl)-2,6-dioxo-5-acetoxypiperidine | HCID 22241189 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-[4-(2-Methoxyacetylamino)-1,3-dioxoisoindolin-2-yl]-2,6-dioxo-5-acetoxypiperidine | HCID 22241198 | — |
Reaction Steps
A solution of 3-(4-amino-1,3-dioxoisoindolin-2-yl)-2,6-dioxo-5-acetoxypiperidine (1 g, 3.5 mmol) and methoxyacetyl chloride (0.38 g, 3.5 mmol) in tetrahydrofuran (20 mL) is heated at reflux for 1 hour. The solvent is removed in vacuo to give 3-[4- (2-methoxyacetylamino)-1,3-dioxoisoindolin-2-yl]-2,6-dioxo-5-acetoxypiperidine which is further purified by column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06458810B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-25dfd1bea26b4e5c8c33eac36cdb4fea |
| Source note | uspto-grants-2002_10 |