Hydrochloric Acid → (S)-1-(4-Fluorophenyl)-ethylamine

Participants

Reaction Steps

A mixture of the crude product of Step 2 (1.2 g, 7.3 mmol), conc. HCl (1 ml in 50 ml CH3OH) and Pd/C (10% w/w) (140 mg) was hydrogenated at 60 psi for 4 hr. After removal of the solvent, the residue was redissolved in 20 ml water and washed with ether. The aqueous layer was then basified to pH 11 and extracted with ether. The ether solution was dried and solvent evaporated to give 1.1 gram of (S)-p-fluoro-α-methylbenzylamine.

Provenance & Evidence