反应详情

N-Iodosuccinimide (3.08 g) was added under ice cooling to a solution of 2.28 g of 7-methylthioimidazo[5,1-b]thiazole in dichloromethane. The mixture was stirred at room temperature for7 hr. Saturated brine was added to the reaction mixture, followed by separation. The organic layer was washed with a dilute aqueous sodium thiosulfate solution and saturated brine in that order, and then dried over anhydrous magnesium sulfate. The solvent was removed by distillation. The residue was purified by column chromatography on silica gel (ethyl acetate:dichloromethane=1:1) to give 3.78 g of 5-iodo-7-methylthioimidazo[5,1-b]thiazole.

1. customfollowed by separation
2. washThe organic layer was washed with a dilute aqueous sodium thiosulfate solution and saturated brine in that order
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was removed by distillation
5. customThe residue was purified by column chromatography on silica gel (ethyl acetate:dichloromethane=1:1)