Ethanol → HCID 54429101, compound

HRID 989934Notes

Reaction equation

HRID 989934 reaction equation
[OH:1][C@@H:2]([CH:6]([CH3:8])[CH3:7])[C:3]([OH:5])=[O:4].[CH3:9][O:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15]Cl)=[CH:13][CH:12]=1.C(O)C>ClCCl>[OH:1][C@@H:2]([CH:6]([CH3:8])[CH3:7])[C:3]([O:5][CH2:15][C:14]1[CH:17]=[CH:18][C:11]([O:10][CH3:9])=[CH:12][CH:13]=1)=[O:4]

Participants

5

Reactant 3

HCID 702EthanolHCID 699934-Methyloxybenzyl chlorideHCID 853180(S)-2-Hydroxy-3-methylbutanoic acid

Product 1

HCID 54429101HCID 54429101, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-hydroxy-3-methyl-(S)-(+)-butyric acid (1.77 g) was esterified by alkylation with 4-methoxybenzyl chloride by the method described in Example A-I-1, step a. The title compound (3.10 g) was obtained after silica gel column chromatography (0, 1, 2% ethanol in dichloromethane). Rf (2%MeOH/CHCl3) 0.50.

Sources & evidence

ORD record
ord-65b276e9b5424f77b60df6bcd8194eba
Source dataset
uspto-grants-2002_10
Patent number
US06458772B1

Reaction notes

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