反应详情

To a solution of N-trityl-L-valine (5.5 g, 15.2 mmole), 2-allyl-1,3-propandiol (4.4 g, 38 mmol), N,N-dimethylamino pyridine (183 mg, 1.5 mmol) in dichloromethane (120 ml) was added DCC (3.5 g, 16.7 mmol). The reaction was kept under reflux overnight. After filtration through Celite, the organic phase was washed with sodium hydrogen carbonate aqueous solution and dried. Silica gel column chromatography gave 4.6 g intermediate 1-O—(N-trityl-L-valyl)-2-allyl-1,3-propandiol.

1. temperatureunder reflux overnight
2. filtrationAfter filtration through Celite
3. washthe organic phase was washed with sodium hydrogen carbonate aqueous solution
4. customdried