HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester → N-(4-Bromo-3-methyl-5-isoxazolyl)-2-(carbomethoxy)thiophene-3-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiophenecarboxylic acid, 3-(chlorosulfonyl)-, methyl ester | HCID 2736733 | — |
| Reactant | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| Product | N-(4-Bromo-3-methyl-5-isoxazolyl)-2-(carbomethoxy)thiophene-3-sulfonamide | HCID 10833686 | 73% |
Reaction Steps
N-(4-Bromo-3-methyl-5-isoxazolyl)-2-(carbomethoxy)thiophene-3-sulfonamide was prepared in the same manner as described in Example 10 from 5-amino-4-bromo-3-methylisoxazole and 2-(carbomethoxy)thiophene-3-sulfonyl chloride in 73% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 198-200° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06458805B2 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-ffe307328f4b41e4be0a670278fe7ef9 |
| Source note | uspto-grants-2002_10 |