Sulfuryl chloride → HCID 17798059, compound

HRID 990063Notes

Reaction equation

HRID 990063 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][CH2:7][C:8]2[S:9][CH:10]=[CH:11][C:12]=2[S:13](N2C=CC=C2)(=[O:15])=[O:14])=[CH:4][CH:3]=1.[K].S(Cl)([Cl:27])(=O)=O>>[CH3:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][CH2:7][C:8]2[S:9][CH:10]=[CH:11][C:12]=2[S:13]([Cl:27])(=[O:15])=[O:14])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 24648Sulfuryl chlorideHCID 5462222PotassiumHCID 54482334HCID 54482334, compound

Product 1

HCID 17798059HCID 17798059, compoundYield 51%

Procedure

2-[(4-Methyl)phenethyl]thiophene-3-sulfonyl chloride was prepared, as described in Example 15E, using N-{2-[(4-methyl)phenethyl]thiophene-3-sulfonyl}pyrrole by basic hydrolysis (KOH/ethanol) of the sulfonamide to the corresponding potassium salt followed by conversion of the salt to the corresponding sulfonyl chloride in 51% yield.

Sources & evidence

ORD record
ord-b464d3aa66484496b26b629c3e15866a
Source dataset
uspto-grants-2002_10
Patent number
US06458805B2

Reaction notes

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