4-Bromo-3-methylisoxazol-5-amine → HCID 23445593, compound

HRID 990064Notes

Reaction equation

HRID 990064 reaction equation
[CH3:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][CH2:7][C:8]2[S:9][CH:10]=[CH:11][C:12]=2[S:13](Cl)(=[O:15])=[O:14])=[CH:4][CH:3]=1.[NH2:19][C:20]1[O:24][N:23]=[C:22]([CH3:25])[C:21]=1[Br:26]>>[Br:26][C:21]1[C:22]([CH3:25])=[N:23][O:24][C:20]=1[NH:19][S:13]([C:12]1[CH:11]=[CH:10][S:9][C:8]=1[CH2:7][CH2:6][C:5]1[CH:17]=[CH:18][C:2]([CH3:1])=[CH:3][CH:4]=1)(=[O:15])=[O:14]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 17798059HCID 17798059, compound

Product 1

HCID 23445593HCID 23445593, compoundYield 52%

Procedure

N-(4-Bromo-3-methyl-5-isoxazolyl)-2-[(4-methyl) phenethyl]thiophene-3-sulfonamide was prepared, as described in Example 10, using 2-[(4-methyl)phenethyl]thiophene-3-sulfonyl chloride and 5-amino-4-bromo-3-methylisoxazole in 52% yield.

Sources & evidence

ORD record
ord-a2aa261bbbb2476a8753f3ede3958e9c
Source dataset
uspto-grants-2002_10
Patent number
US06458805B2

Reaction notes

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