t-butyl-[4-(2S)-oxiranylmethoxy-phenoxy]-diphenylsilane → (2S)-1-{[4-({[5-(4-methoxyphenyl)-1,2,4-oxadiazol-3-yl]methyl}sulfonyl)phenethyl]amino}-3-{4-[(triisopropylsilyl)oxy]phenoxy}-2-propanol

Participants

Reaction Steps

This material was prepared as described in Example 11 from tert-butyl{4-[(2S)oxiranylmethoxy]phenoxy}diphenylsilane (0.45 g, 1.124 mmol) and 4-({[5-(4-methoxyphenyl)-1,2,4-oxadiazol-3-yl]methyl}sulfonyl)phenethylamine (0.70 g, 1.875 mmol). This procedure afforded 0.570 g of the title compound as a white foam.

Provenance & Evidence