HRID990087

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)[Si](Oc1ccc(OC[C@@H]2CO2)cc1)(c1ccccc1)c1ccccc1

HCID11327180

t-butyl-[4-(2S)-oxiranylmethoxy-phenoxy]-diphenylsilane

C25H28O3Si

HCID23389086

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)c1nc(CSc2ccc(CCNC[C@H](O)COc3ccc(O[Si](c4ccccc4)(c4ccccc4)C(C)(C)C)cc3)cc2)no1

HCID59886865

未命名化合物

收率 12.9%

PROCEDURE

实验过程

Following the procedure described in Example 14 using the amine of Example 30 (0.481 g, 1.565 mmol) and tert-butyl{4-[(2S)oxiranylmethoxy]phenoxy}diphenylsilane (0.697 g, 1.721 mmol) afforded 0.140 g of the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5e39904143764b038ff86f5dcf737e2c
来源数据集: uspto-grants-2002_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06458817B1
来源说明: uspto-grants-2002_10

反应 SMILES

[C:1]([C:5]1[O:9][N:8]=[C:7]([CH2:10][S:11][C:12]2[CH:20]=[CH:19][C:15]([CH2:16][CH2:17][NH2:18])=[CH:14][CH:13]=2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:21]([Si:25]([O:38][C:39]1[CH:44]=[CH:43][C:42]([O:45][CH2:46][C@@H:47]2[CH2:49][O:48]2)=[CH:41][CH:40]=1)([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)([CH3:24])([CH3:23])[CH3:22]>>[Si:25]([O:38][C:39]1[CH:44]=[CH:43][C:42]([O:45][CH2:46][C@@H:47]([OH:48])[CH2:49][NH:18][CH2:17][CH2:16][C:15]2[CH:14]=[CH:13][C:12]([S:11][CH2:10][C:7]3[N:6]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[O:9][N:8]=3)=[CH:20][CH:19]=2)=[CH:41][CH:40]=1)([C:21]([CH3:22])([CH3:24])[CH3:23])([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1