Water → HCID 18419728, compound

Participants

Reaction Steps

Isonipecotic acid (6.42 g) was dissolved in a 4:1 mixture of tetrahydrofuran:water (100 ml), potassium carbonate (10.3 g) and di-tert-butyl dicarbonate (11.4 g) were added and stirred at room temperature over night. The tetrahydrofuran was removed in vacuo and the residue dispersed between water (100 ml) and ethyl acetate (100 ml), the aqueous phase was extracted with ethyl acetate (3×75 ml). The combined organics were washed with brine and dried (MgSO4). The solution was filtered, evaporated to dryness to afford a white solid of N-butoxycarbonylpiperidine-4-carboxylic acid(11.6 g).

Provenance & Evidence