Hydrochloric Acid → HCID 18419683, compound

Participants

Reaction Steps

The compound of step (iii) was re-dissolved in methanol to the volume of 400 ml. Then to the solution were added 5% Pd/C and concentrated HCl (50 ml). The mixture was hydrogenated for 24 hr at hydrogen pressure of 100 atm and temperature 90° C. The mixture was cooled, filtered and evaporated. The resulting oily residue was dissolved at reflux in isopropanol (100 ml) and to the solution was added concentrated HCl (50 ml). The mixture was allowed to crystallise at 5° C. for 3 days and then filtered to give the title compound (135 g).

Provenance & Evidence