HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(trifluoromethyl)pyrimidine-5-carboxylic Acid → N-[[1-[4-(Methylsulfonyl)butyl]cyclobutyl]thioxomethyl]-4-[[[4-(trifluoromethyl)pyrimidin-5-yl]carbonyl]amino]-L-phenylalanine Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(trifluoromethyl)pyrimidine-5-carboxylic Acid | HCID 11608075 | — |
| Reactant | 4-amino-N-[[1-[4-(methylsulfonyl)butyl]cyclobutyl]thioxomethyl)-L-phenylalanine methyl ester | HCID 53651737 | — |
| Reactant | N-[[1-[4-(methylsulfonyl)butyl]cyclobutyl]thioxomethyl]-4-[[[2-(trifluoromethyl) pyrimidin-5-yl]carbonyl]amino]-L-phenylalanine methyl ester | HCID 54401295 | — |
| Product | N-[[1-[4-(Methylsulfonyl)butyl]cyclobutyl]thioxomethyl]-4-[[[4-(trifluoromethyl)pyrimidin-5-yl]carbonyl]amino]-L-phenylalanine Methyl Ester | HCID 12042617 | 32% |
Reaction Steps
Using the general procedure described in example 45, starting with 4-(trifluoromethyl)pyrimidine-5-carboxylic acid and 4-amino-N-[[1-[4-(methylsulfonyl)butyl]cyclobutyl]thioxomethyl)-L-phenylalanine methyl ester, N-[[1-[4-(methylsulfonyl)butyl]cyclobutyl]thioxomethyl]-4-[[[2-(trifluoromethyl) pyrimidin-5-yl]carbonyl]amino]-L-phenylalanine methyl ester was prepared in 32% yield as an amorphous colorless solid. HR MS: Obs. mass, 601.1766. Calcd. mass, 601.1766 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06458844B2 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-49d952e4cd094551be3c147e7be7587c |
| Source note | uspto-grants-2002_10 |