(+-)-3-Quinuclidinol → HCID 9910369, compound

HRID 990211Notes

Reaction equation

HRID 990211 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[C:4]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:3]=1.[N:22]12[CH2:29][CH2:28][CH:25]([CH2:26][CH2:27]1)[CH:24]([OH:30])[CH2:23]2>>[Cl-:1].[O:15]([C:4]1[N:5]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:7]=[C:2]([N+:22]23[CH2:29][CH2:28][CH:25]([CH2:26][CH2:27]2)[CH:24]([OH:30])[CH2:23]3)[N:3]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 15381(+-)-3-QuinuclidinolHCID 180882-chloro-4,6-diphenoxy-1,3,5-triazine

Product 1

HCID 9910369HCID 9910369, compound

Procedure

The operation was carried out in the same manner as in Preparation Example 1 but using 6.00 g (0.02 mols) of a 2-chloro-4,6-diphenoxy-1,3,5-triazine and 2.54 g (0.02 mols) of a 3-quinuclidinol to obtain 8.38 g (yield, 98.1%) of white crystals of a 1-(4,6-diphenoxy-1,3,5-triazin-2-yl)-3-hydroxyquinuclidinium chloride represented by the following general formula (XIV)

Workup

  1. customThe operation was carried out in the same manner as in Preparation Example 1
  2. customto obtain

Sources & evidence

ORD record
ord-91b85490ad364c36acf414ed28756aed
Source dataset
uspto-grants-2002_10
Patent number
US06458948B1

Reaction notes

Loading…