HCID 178524453, compound → HCID 178524454, compound

Participants

Reaction Conditions

Reaction Steps

In a 1.3 liter stirred autoclave fitted with stirrer, temperature sensor, and riser tube, 666 g of pyridine-2,3-dicarboxylic acid N-benzylimide and 28.2 g of 5% by weight palladium-on-carbon were suspended in 959 g of toluene. The autoclave was then flushed, hydrogen was introduced, and the autoclave was heated at a reaction temperature of 80° C. as described in Example 1. Work-up of the reaction mixture as described in Example 1 gave 618 g of piperidine-2,3-dicarboxylic acid N-benzylimide in a purity of 98.7% (GC area percent).

Provenance & Evidence