HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(1-Hydroxy-4-chlorobutyl)-alpha,alpha-dimethylphenylacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 2-(4-(4-Chlorobutanoyl)phenyl)-2-methylpropanoic acid | HCID 10923567 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(1-Hydroxy-4-chlorobutyl)-alpha,alpha-dimethylphenylacetic acid | HCID 22269403 | — |
Reaction Steps
To a solution of 50 mg of 4-(4-chloro-1-oxobutyl)-α,α-dimethylphenylacetic acid in 3 mL of methanol was added 50 mg of NaBH4. The mixture was stirred for 30 minutes, acidified with 2N HCl, and the methanol was removed in vacuo. The concentrate was extracted with EtOAc. The organics were dried over Na2SO4, filtered, and concentrated to afford 4-(1-hydroxy-4-chlorobutyl)-α,α-dimethylphenylacetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06458958B1 |
| Source dataset | uspto-grants-2002_10 |
| ORD ID | ord-58f43a5b5c04406a93a6120dda94682f |
| Source note | uspto-grants-2002_10 |