Potassium bis(trimethylsilyl)amide → HCID 136036463, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of the title compound of Example 124 (100 mg, 0.20 mmol) and potassium bis(trimethylsilyl)amide (204 mg, 1.02 mmol) in pyridine-2-methanol (2 ml) was stirred at 110° C. for 18 hours, then cooled. The solvent was removed by Kugelrohr distillation, and the residue was purified by column chromatography on silica gel, using dichloromethane: methanol (95:5) as eluant. This product was triturated with ether to afford the title compound (8 mg, 7%) as a solid.

Provenance & Evidence