Hexafluorophosphate → HCID 18420299, compound

Participants

Reaction Steps

N-{2-Oxo-2-{di(phenylmethyl)amino}ethyl}-4-acetylbenzamide: To a solution of 4-acetylbenzoic acid (1.21 g, 7.37 mmol) in DMF (35 mL) was added successively the product of the preceding section (b) (2.03 g, 7.0 mmol), DIPEA (4.3 mL, 24.5 mmol) and BOP.PF6 (3.25 g, 7.37 mmol). The resulting solution was stirred at room temperature for 2 h, then diluted with EtOAc, washed serially with H2O, 4N aqueous HCl, saturated NaHCO3, and brine, dried (MgSO4) and concentrated under reduced pressure to give N {2-oxo-2-{di(phenylmethyl)amino}ethyl}-4-acetylbenzamide (2.70 g, 99% yield) as a light yellow foam: 1H NMR (400 MHz, DMSO-d6) 8 8.89 (t, 1H, J=5.7 Hz), 8.05 (d, 2H, J=8.4 Hz), 8.00 (d, 2H, J=8.4 Hz), 7.24-7.44 (m, 10 H), 4.61 (s, 2H), 4.51 (s, 2H), 4.25(d, 2H, J=5.7 Hz), 2.52 (s, 3H); MS (FAB) m/z 401 (MH)+. This product was used as such in the next reaction (section (d)).

Provenance & Evidence